Yanhua Rao

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unveiled insights into GSK4418959 (IDE275), a Werner (WRN) helicase inhibitor that binds WRN reversibly and demonstrated the ability to induce DNA damage in solid tumors with high microsatellite instability, while sparing microsatellite stable cells.

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Speaking history

AACR Drug Discovery and Development (AACR D3)

21 July 2026 Boston, United States “GSK4418959 (IDE275): WRN Helicase Inhibitor in Cancers with High Microsatellite Instability”

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