University of Calgary · company speakers →
Dr. Paola Neri will discuss the Immune predictors of response to chimeric antigen receptor (CAR) T and bispecific T cell therapy in multiple myeloma (MM). She will start by describing the mechanisms of tumor escape that allow MM progression and development of immune dysfunction. Next, she will review the T-Cell based strategies developed to overcome immune escape with a focus on CAR-T and bispecific T cell therapy. Lastly, Dr. Neri will discuss the causes of resistance to these therapies and how a comprehensive genomic analysis of the tumor together with the study of the immune cell repertoire can help to identify patients with the highest likelihood of respond to these therapies and lead to the development of prevention strategies.
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