Michael Tweedle

Emeritus Stefanie Spielman Professor of Cancer Imaging and Professor of Radiology · The Ohio State University College of Medicine and James Comprehensive Cancer Center · company speakers →

Michael F. Tweedle, PhD is Emeritus Stefanie Spielman Professor of Cancer Imaging and Professor of Radiology at The Ohio State University College of Medicine and James Comprehensive Cancer Center. His education was at Knox College (BA Chemistry), Rice University (PhD Physical Chemistry) and Stanford University (NIH Research Service Fellow). His experience in diagnostic imaging began as a research scientist at New England Nuclear, Inc. In 1981 he invented the first catalyst for production of Tc radiopharmaceutical myocardial perfusion agents, and early targeted molecular imaging (MI) agents using monoclonal antibodies at NEN/DuPont Pharmaceuticals. In 1986, working with E.R. Squibb and Sons, he invented and developed the first novel macrocyclic GBCA (Gd-based MRI Contrast Agent), ProHance TM (gadoteridol), and the unsymmetrical macrocyle class (used in > 150 million MRI patients and in commercial 177 Lu radiotherapeutics). As President, CEO and chief scientist at Bracco Research USA Inc, he and his team created in early 2000s two new clnically tested Molecular Imaging agents: a first in class targeted theranostic for prostate and breast cancer ( 177 LuAMBA), and a first in class sub nM VEGF-R2 angiogenesis receptor-targeting peptide used in the targeted ultrasound contrast agent now in Phase-II clinical trials (BR55). He transiioned toacademics in 2009, focusing research on cancer imaging theranostics and teaching in entrepreneurial development. He is Associate Editor for contrast agents for the journals, Radiology, Magnetic Resonance Imaging and Investigative Radiology, served on NIH study sections in SBIR and Image Guided Therapy, has served on Expert Councils at the US Pharmacopeia, the elected Boards and as Officer of four professional societies, academic Scientific Advisory Boards in molecular Imaging, and on Scientific Advisory and governing Boards of public and private biopharmaceutical and chemical companies, and served on the Dean’s Scientific Advisory Board of New York University’s School of Science. He has authored over 200 publications including 105 peer-reviewed original research papers, 40 issued US patents (8 pending), 13 book chapters, and 40 reviews and editorials, with >10,000 citations and an H-Index of 54. He was awarded The Harry Fischer Medal in 2005, elected a Fellow of the World Molecular Imaging Society in 2023, and elected to the National Academy of Inventors in 2023.

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