Matthias Farlik

PhD · Medical University Vienna · company speakers →

Macrophages play critical roles in cancer and in the response to pathogens. We recently discovered that macrophages in colorectal cancer mediate immunosuppression through the expression of an array of immune-checkpoint molecules driven by interactions with cancer associated fibroblasts. Here we use the Xenium spatial transcriptomics platform to visualize macrophage heterogeneity in the CRC tumor microenvironment. We discovered associations with other cell types and niche formation and identified unexpected phenotypic similarities to macrophages forming skin granulomas in a patient diagnosed with non-langerhans cell histiocytosis. The presentation will include technological aspects and “lessons learned“ from the use of the Xenium technology.

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