Marina Picciotto

Yale University · company speakers →

Acetylcholine (ACh) transmission is critical for cognition and attention, but is also released in response to stress. Importantly, ACh levels are dysregulated in the brains of human depressed subjects. Using the example of ACh signaling in stress-relevant behaviors, this session will present data using genetically-encoded fluorescent ACh sensors, explore what we can conclude about human stress disorders from mouse models, and address the question of what a neuromodulator is in the context of classical neurotransmitter signaling.

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