Joseph S. Takahashi

University of Texas Southwestern Medical Center, Howard Hughes Medical Institute · company speakers →

The molecular basis of circadian clocks involves a 24-hour autoregulatory transcriptional network that is cell-autonomous and widely expressed. The suprachiasmatic nucleus acts as master pacemaker, but peripheral oscillators can respond to proximal signals. In addition to behavior and physiology, the clock gene network interacts directly with many other pathways in the cell. With respect to metabolism, the timing of nutrient consumption is critical, and restricting the timing of feeding has many health benefits that impact aging, health span, and longevity.

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