Giovanna Mallucci, MD, PhD

Altos Labs · company speakers →

Untreatable neurodegenerative disorders are an ever-increasing problem as society ages. This talk will focus on how increasing neuronal resilience and functional rejuvenation can slow and prevent these diseases. The speaker will discuss their discoveries on dysregulated PERK-UPR signaling in mediating neurodegeneration and how small molecules and drugs targeting the pathway prevent it. The speaker will also show how they used the biology of hibernation to drive synapse regeneration for neuroprotection via the cold shock protein, RBM3, and how they are translating these approaches to treat dementia.

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