Anthony A. Hyman

Max Planck Institute of Cell Biology & Genetics · company speakers →

Cells organize many of their biochemical reactions by formation and dissolution of non-membrane-bound compartments. Recent experiments show that a common mechanism for such biochemical organization is phase separation of unstructured proteins to form liquid-like compartments. These liquid-like compartments can be described by principles elucidated from condensed-matter physics and are therefore termed biomolecular condensates. This lecture will cover the relationship between the formation of liquid-like compartments, quality control mechanisms that preserve the liquid-like state, and the onset of aggregated-protein pathology that is commonly observed in neurodegenerative diseases.

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